Sumatriptan gsk

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It is not clear whether this finding was due to an effect on males or females or both. In developmental toxicity studies in rats and rabbits, oral administration of sumatriptan to pregnant animals was associated with embryolethality, fetal abnormalities, and pup mortality.

The mg dose may be achieved by the administration of a single 5-mg dose in each nostril. Dimetotiazine Dotarizine Iprazochrome Oxetorone Pizotifen. Heart problems may lead to death. In 2 trials, a 5-mg dose was also evaluated. Injection site reaction a. Patients with little or no clinical disability b. Especially tell your healthcare provider if you take anti-depressant medicines called: For more information, go to www. The pharmacokinetics of sumatriptan in the elderly mean age: Fertility studies of sumatriptan using the intranasal route have not been conducted.

Such reactions can be life threatening or fatal.

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Also, patients with migraine may be at increased risk of certain cerebrovascular events e. Serotonin syndrome symptoms may include mental status changes e.

5.1 Myocardial Ischemia, Myocardial Infarction, and Prinzmetal’s Angina

There were no statistically significant differences between the 5- and mg dose groups in any trial. Some of these reactions occurred in patients without known CAD.

Note that, in general, comparisons of results obtained in trials conducted under different conditions by different investigators with different samples of patients are ordinarily unreliable for purposes of quantitative comparison.

Medication overuse headache may present as migraine-like daily headaches, or as a marked increase in frequency of migraine attacks. The makers of these brands are not affiliated with and do not endorse GlaxoSmithKline or its products. In a number of cases, it appears possible that the cerebrovascular events were primary, the 5-HT 1 agonist having been administered in the incorrect belief that the symptoms experienced were a consequence of migraine when they were not.

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A cardiovascular evaluation is recommended for geriatric patients who have other cardiovascular risk factors e. While holding your head level, gently breathe in through your nose and out through your mouth for 10 to 20 seconds see Figure F. Generally not associated with myocardial ischemia; evaluate for coronary artery disease in patients at high risk.

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The efficacy of IMITREX Tablets was unaffected by presence of aura; duration of headache prior to treatment; gender, age, or weight of the subject; relationship to menses; or concomitant use of common migraine prophylactic drugs e.

Each pack contains a Patient Information and Instructions for Use leaflet. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice. Instruct patients to use injection sites with an adequate skin and subcutaneous thickness to accommodate the length of the needle.

Sumatriptan 50mg film-coated Tablets.